ToF-SIMS Imaging Elucidates Spinal Cord Lipid Dynamics in ALS

Hanrieder et al. published their paper on elucidation of spatial lipid dynamics in post mortem spinal cord of patients suffering from Amyotrophic Lateral Sclerosis. The data reveal an ALS associated increase of proinflammatory lipid mediators and metabolites in confined regions of the ventral spinal cord. The data give insight in potential mechanisms underlying motor neuron degeneration in ALS. The paper is available online at Nature’s Scientific Reports: www.nature.com/srep/2014/140612/srep05266/full/srep05266.htmlFigure 5

ASMS here we come

Next week the NCIMS will present several posters at ASMS2014 (62nd ASMS Conference on Mass Spectrometry and Allied Topics) in Baltimore. Come meet us there for new insights into imaging mass spectrometry! Check out our posters in the “Imaging MS: Small Molecules and Drugs”, “Imaging MS: Method Development II” and “Imaging MS: Instrumentation”-sessions.

NEW PAPER!!! Exciting Data on ToF SIMS Imaging in Molecular Neurotoxicology

Hanrieder et al. at the NCIMS just published a study on ToF SIMS based molecular imaging for studying effects of neonatal exposure to the environmental toxin BMAA. In an animal model, neurochemical long term changes in the hippocampus upon neurotoxin exposure were studied. The results show BMAA induced metabolite regulations in distinct hippocampal regions that are mainly associated with protein aggregation , neuronal degeneration and astrogliosis. The Paper is now online at ACS Chemical Neuroscience http://dx.doi.org/10.1021/cn500039b cn-2014-00039b_0009