Jörg Hanrieder

 

people_jorg

 

 

 

 

 


Postdoctoral Fellow (funded by VR), Research area: Analytical Chemistry and Neurochemistry

Contact:
Chalmers University of Technology
Analytical Chemistry
Kemivägen 10 (plan5)
41296 Gothenburg

Room 5019
Tel.: +46 (0) 31772 3050
Mail: jorg.hanrieder@chalmers.se

Bio

2011-07-01 - PRESENT
Chalmers University of Technology, Gothenburg, Sweden
Dept. Chem. and Biol. Engineering, Analytical Chemistry
Postdoctoral Fellow (funded by the swedish research council, VR)

2011-01-01 - 2011-06-30
Uppsala University, Uppsala, Sweden
Dept. Pharmaceutical Bioscience, Toxicology and Drug Safety
Research Associate

2006-01-06 - 2010-12-31
Uppsala University, Uppsala, Sweden
Dept. Physical and Analytical Chemistry, Analytical Chemistry
Ph.D. Student, Supervisor: Prof. Jonas Bergquist, Prof Ulf Hellman, Dr. Malin Andersson
PhD thesis: Title: "Cerebrum Illuminans - Mass Spectrometric Analysis of Protein and Peptide Dynamics in Neurological Diseases"

2005-09-15 - 2005-12-15
The University of Adelaide, Adelaide, SA, Australia
School of Molecular and Biomedical Science
Research Assistant

2005-04-01 - 2005-06-01
Ohio University, Athens, OH, USA
Visiting scholar at the Department of Chemistry and Biochemistry, Medicinal Chemistry
(ISEP-scholarship of the German Academic Exchange Service DAAD)

2000-10-01 - 2005-07-31
University of Leipzig, Leipzig, Germany
Chemistry (Dipl.Chem.)

fig0

Research
The cellular processes underlying neurodegenerative disorders such as Alzheimer’s- (AD) and Parkinson’s -disease (PD) still remain largely elusive. These deficits and the large complexity of the nervous system strongly emphasize the need for appropriate research tools that feature the necessary sensitivity and specificity in order to delineate the molecular events and interactions on a subcellular level. Hence, a change of paradigm from classic molecular biology techniques to advanced analytical technologies such as mass spectrometry is of essential relevance. In particular, mass spectrometry based molecular imaging (IMS), facilitates comprehensive and untargeted analysis at subcellular length scales allowing us to deepen our understanding of inter- and intra-cellular molecular processes in neurodegenerative pathologies.

The overall goal of my research is therefore to elucidate molecular events on a subcellular level that underlie nerve cell degeneration in PD and AD including abnormal protein membrane interactions. Here, a major focus lies on the development and application of molecular imaging techniques based on cluster-ionbeam and laser ionization mass spectrometry (MS). These technologies are utilized for investigating chemical mechanisms of neurodegeneration on a subcellular level in cell- and animal models of AD and PD.

Latest Publications
Hanrieder J., Phan T.N., Kurczy M., Ewing A.G. “Imaging Mass Spectrometry in Neuroscience” ACS Chem. Neurosci.2013 (in print)

Hanrieder J., Ekegren T., Andersson M., Bergquist J. ”MALDI Imaging of Post Mortem Human Spinal Cord in Amyotrophic Lateral Sclerosis” J. Neurochem. 2013. 124(5): 695-707

Hanrieder J., Ljungdahl A., Andersson M. "MALDI Imaging Mass Spectrometry of Neuropeptides in Parkinson’s Disease" J. Vis. Exp. 14(60). pII: 3445

Ljungdahl A., Hanrieder J., Fälth M., Bergquist J., Andersson M “Imaging Mass Spectrometry Reveals Elevated Nigral Levels of Dynorphin Neuropeptides in L-DOPA-induced Dyskinesia in Rat Model of Parkinson’s Disease” PLoS One 2011, 6 (9) e25653

Hanrieder J., Ljungdahl A., Fälth M., Bergquist J., Andersson M "L-DOPA induce Dyskinesia is Associated with Regional Increase of Striatal Dynorphin Peptides as Elucidated by Imaging Mass Spectrometry" Mol. Cell. Proteomics, 2011 (Published online 6th Juli)

Hanrieder J, Wicher G, Bergquist J, Andersson M, Fex-Svenningsen Å. “MALDI mass spectrometry based molecular profiling of neural cells for prediction in mammalian brain” Anal. Bionanal. Chem. 2011, 401 (1), 135-147

Hanrieder J., Wetterhall M., Hillered L., Enblad P., BergquistJ.“Differential Proteomic Analysis of Human Ventricular CSF for Monitoring Traumatic Brain Injury Biomarkers“ J. Neurosci. Meth. 2009, 177(2), 469-478

Ekegren T., Hanrieder J., Bergquist J., “Clinical Perrspectives of High Resolution Mass Spectrometry based Proteomics in Neuroscience - Exemplified in Amyothrophic Lateral Sclerosis Biomarker Discovery” J. Mass Spectrom. 2008, 43(5), 559-571

Ekegren T., Hanrieder J., Aquilonius S. M., Bergquist J., “Focused Proteomics in Post-Mortem Human Spinal Cord” J. Proteome Res. 2006, 5(9), 2364-2371